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Supplementary Materials Data Availability Statement The datasets used and/or analyzed during the current study are available as MS Excel files (.xlsx) and RevMan file (.rm5) from the corresponding author upon reasonable request.

Importantly, the current evidence gap should not be interpreted as evidence of ineffectiveness

In SCA3, ASOs have been used either to decrease overall ATXN3 levels or to generate a truncated ATXN3 which lacks the polyQ expansion [280, 281]

How to dose Bpc 157 Sources: Dosing for BPC 157 typically ranges from 300 to 500 micrograms , administered two to three times per week , or potentially up to five days a week if desired